根据上海市医学会《关于推荐2023年度上海医学科技奖的通知》（沪医会(2023)48号）的有关规定，现将我单位提名2023年度上海医学科技奖的项目进行公示。
项目名称：靶向肿瘤微环境的分子影像诊疗一体化新策略及其基础研究
完成人（完成单位）：黄钢（上海健康医学院），田启威（上海健康医学院），杨浩（上海健康医学院），靳明明（上海健康医学院），杨仕平（上海师范大学），邹华华（上海健康医学院），安璐（上海师范大学），薛峰峰（上海健康医学院）
公示时间：2023年10月18日-2023年10月24日
公示期间，任何单位或者个人对公示项目持有异议的，以书面形式向科技处提出，并提供必要的证明文件。为便于核实、查证，确保实事求是、公正地处理异议，提出异议的单位或者个人应当表明真实身份，并提供联系方式。个人提出异议的，应当在书面异议材料上签署真实姓名；以单位名义提出异议的，应当加盖本单位公章。凡匿名异议和超出期限的异议一般不予受理。
联系人：张霞，电话：021-65882010，邮箱：zhangx_10@sumhs.edu.cn。
科技处
上海健康医学院
2023年10月18日
附公示内容
项目名称：靶向肿瘤微环境的分子影像诊疗一体化新策略及其基础研究
完成人（含排序）：黄钢，田启威，杨浩，靳明明，杨仕平，邹华华，安璐，薛峰峰
完成单位（含排序）：上海健康医学院，上海师范大学
提名单位：上海健康医学院
项目目的：本项目旨在阐明肿瘤微环境及相关成分对于肿瘤恶性进展的新机制，并以这些微环境调控模式及相关化学反应为触发开关，设计开发特异性的诊疗一体化的分子影像新探针或试剂，同时筛选靶向微环境调控的安全、稳定的新药物及中药单体，期望为肿瘤的临床精准诊疗提供新的理论依据和实践指导。
代表性论文情况：
序号 | 论文 | 第一作者 | 通讯作者 | 发表年份 | 在线发表时间 | 影响因子 |
1. | Lu An, Xiaodong Wang, Xichuan Rui, Jiaomin Lin, Hong Yang, Qiwei Tian, Cheng Tao, Shiping Yang, The In Situ Sulfidation of Cu2O by Endogenous H2S for Colon Cancer Theranostics. Angewandte Chemie International Edition 2018, 57, 15782-15786. | An, Lu; Wang, Xiaodong | Tian, Qiwei; Yang, Shiping | NOV 26 2018 | OCT 11 2018 | 16.6 |
2. | Lu An, Chengbin Wang, Qiwei Tian, Cheng Tao, Fengfeng Xue, Shiping Yang, Xuesu Zhou, Xiaoyuan Chen, Gang Huang, NIR-II laser-mediated photo-Fenton-like reaction via plasmonic Cu9S8 for immunotherapy enhancement. Nano Today 2022, 43, 101397. | An, Lu | Tian, Qiwei; Yang, Shiping; Chen, Xiaoyuan; Huang, Gang | APR 2022 | JAN 18 2022 | 17.4 |
3. | Dongliang Wang, Chaoshuai Zhao, Fei Xu, Aimi Zhang, Mingming Jin, Kunchi Zhang, Liu Liu, Qian Hua, Jian Zhao, Jianjun Liu, Hao Yang, Gang Huang, Cisplatin-resistant NSCLC cells induced by hypoxia transmit resistance to sensitive cells through exosomal PKM2. Theranostics 2021, 11, 2860-2875. | Wang, Dongliang | Yang, Hao; Huang, Gang | 2021 | JAN 01 2021 | 12.4 |
4. | Hao Yang, Rongxuan Zhu, Xiaoping Zhao, Liu Liu, Zhaoli Zhou, Li Zhao, Beibei Liang, Wenjing Ma, Jian Zhao, Jianjun Liu, Gang Huang, Sirtuin-mediated deacetylation of hnRNP A1 suppresses glycolysis and growth in hepatocellular carcinoma. Oncogene 2019, 38, 4915-4931. | Yang, Hao; Zhu, Rongxuan | Liu, Jianjun; Huang, Gang | JUN 20 2019 | MAR 11 2019 | 8 |
5. | Hao Yang, Xiaoping Zhao, Jianjun Liu, Mingming Jin, Xiyu Liu, Jun Yan, Xufeng Yao, Xinyi Mao, Nan Li, Beibei Liang, Wei Xie, Kunchi Zhang, Jian Zhao, Liu Liu, Gang Huang, TNFα-induced IDH1 hyperacetylation reprograms redox homeostasis and promotes the chemotherapeutic sensitivity. Oncogene 2023, 42, 35-48. | Yang, Hao | Zhao, Jian; Liu, Liu; Huang, Gang | JAN 3 2023 | NOV 10 2022 | 8 |
6. | Lu An, Mei Cao, Xue Zhang, Jiaomin Lin, Qiwei Tian, Shiping Yang, pH and Glutathione Synergistically Triggered Release and Self-Assembly of Au Nanospheres for Tumor Theranostics. ACS Applied Materials & Interfaces 2020, 12, 8050-8061. | An, Lu | Tian, Qiwei; Yang, Shiping | FEB 19 2020 | JAN 29 2020 | 9.5 |
7. | Mingming Jin, Chunzi Shi, Tian Li, Yue Wu, Cheng Hu, Gang Huang, Solasonine promotes ferroptosis of hepatoma carcinoma cells via glutathione peroxidase 4-induced destruction of the glutathione redox system. Biomedicine & pharmacotherapy，2020, 129, 110282. | Jin, Mingming; Shi, Chunzi; Li, Tian | Hu, Cheng; Huang, Gang | SEP 2020 | JUN 9 2020 | 7.5 |
8. | Mingming Jin, Yue Wu, Yuqing Lou, Xiyu Liu, Yitian Dai, Wenxiao Yang, Congbiao Liu, Gang Huang, Corosolic acid reduces A549 and PC9 cell proliferation, invasion, and chemoresistance in NSCLC via inducing mitochondrial and liposomal oxidative stress. Biomedicine & Pharmacotherapy 2021, 144, 112313. | Jin, Mingming; Wu, Yue; Lou, Yuqing; Liu, Xiyu; Dai, Yitian | Yang, Wenxiao; Liu, Congbiao; Huang, Gang | DEC 2021 | OCT 19 2021 | 7.5 |
9. | Yue Wu, Dongliang Wang, Yuqing Lou, Xiyu Liu, Pinzheng Huang, Mingming Jin, Gang Huang, Regulatory mechanism of α-hederin upon cisplatin sensibility in NSCLC at safe dose by destroying GSS/GSH/GPX2 axis–mediated glutathione oxidation-reduction system. Biomedicine & Pharmacotherapy 2022, 150, 112927. | Wu, Yue; Wang, Dongliang; Lou, Yuqing; Liu, Xiyu | Jin, Mingming; Huang, Gang | JUN 2022 | APR 7 2022 | 7.5 |
10. | Fengfeng Xue, Shuntao Zhu, Qiwei Tian, Ruomeng Qin, Zerong Wang, Gang Huang, Shiping Yang, Macrophage-mediated delivery of magnetic nanoparticles for enhanced magnetic resonance imaging and magnetothermal therapy of solid tumors. Journal of Colloid and Interface Science 2023, 629, 554-562. | Xue, Fengfeng | Tian, Qiwei; Huang, Gang; Yang, Shiping | JAN 2023 | SEP 5 2022 | 9.9 |